Edmond Pradipta Andrianus (2015) Potensi Ekstrak Daun Rumput Mutiara (Hedyotis Corymbosa (L) Lamk) Terhadap Apoptosis Sel Kanker Rongga Mulut Pada Tikus Wistar Jantan Yang Diinduksi Benzo(A) Pirene. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Background: Oral cancer is one of the lethal diseases due to its late diagnose and hard yet costive therapy. A therapy using the ethanol extract of leaf from Hedyotis Corymbosa (L) Lamk that is low price yet easy to be found. The extract contains of 10% ursolic acid that has pro-apoptotic effect in cancer. Purpose: To prove and analyze the best dose of leaf from Hedyotis-corymbosa (L) Lamk ethanol extract to induce apoptosis of oral cancer Methods: This research is the laboratories experimental with post test only control group design. There are 25 Galur-wistar rat as research samples, and divided into four group, namely KK, KP 1 (375 mg/kg BB), KP 2 (750 mg/kg BB), and KP 3 (1500 mg/kg BB). All of this samples were injected by benzo(a)pirene intra muscular in oral twice a week for a month with the dose 8 mg/kg BB. Furthermore,each group was given Hedyotis-corymbosa leaf etanol extract with the dose 375 mg/kg BB, 750 mg/kg BB, and 1500 mg/kg BB for ten days. All samples were sacrificed and processing for histopatological evaluation among group. The data were tabulated and analyze statistically. Result: Median scores of caspase-3 amount in oral cancer from Wistar rats on KK, KP1, KP2, and KP3 are 1, 1, 1.3 and 1.171 respectively Conclusion: Hedyotis corymbosa leaf etanol extract have no effect on apoptosis oral cancer cell.

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