MUHAMAD EDY SANTOSO (2015) STUDI PENGGUNAAN ANTIBIOTIKA GENTAMISIN PADA PASIEN INFEKSI ENDOKARDITIS:Penelitian dilakukan di Departemen Ilmu Departemen Kardiologi dan Kedokteran Vaskular RSUD Dr. Soetomo Surabaya. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Background : Infective Endocarditis is an infection occurred in the heart valves and/or in the area adjacent to heart. Infective Endocarditis are given treatments of antibiotics where used in its high potentiation is gentamicin. The clinical study was evaluate aminoglycoside-induced nephrotoxicity, auto toxicity, and neurotoxicity. Methods : The method was time limited sampling and conducted retrospectively by managing investigation and documentation of data of Health Medical Document of the patients diagnosed with Infective Endocarditis and given therapy of gentamicin antibiotic hospitalized in the Department of Cardiology and Vascular Medicine of Dr. Soetomo Regional Unit Hospital. This purposes were identify the ethiology of Infective Endocarditis, duration of treatment and dose regimentation, and the problems related to the medicine (DRP) including the by-product of the medicine, the interaction with other medicines. Results : the most used doses of therapy used was 2x80 mg (86%). The duration of therapy for patients treated in 2 weeks (72%). Gentamicin therapy was used in combination with ampicillin is the most common combination (72%). Patients had been induced adverse effect were 28%. During the process of therapy, the problem related to the medicine arose; the problems are the interactions with Furosemide, Ibuprofen, Omeprazole, and Digoxin.

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