Nia Wahyuni Febrianti, 020513648 (2010) EFEK EKSTRAK ETANOL BUAH MENGKUDU (MARINDA CIRIFOLIA L.) TERHADAP PROLIFERASI SEL FIBROBLAS. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

The purpose of this researchs verified th e boost up fibroblast cell proliferation of givng extract ethanol to the mengkudu fruit (Morinda citrifo lia L.). Mengkudu have been used hereditary as dill for wound treatment because it is easy to get, cheap, and insignificant side effect. The essence wh ich is consist in mengkudu are scopoletin, anthraquinone one as antimicroba especially bacteria, fungi, and have the main role to solve inflamed and allergy. Vitamin C are one of antioxide and also vital nutrition in wound healing. Proxeronine is alkaloids co mpound also the cause which consist in mengkudu are very active and important in every cells of human body. Xeronine compound of mengkudu are effectives in ac celerating heal th e wound with build procollagenase system and change the sk in tissue system which is die. Identification of effect the Mengkudu fruit (Morinda ci trifolia L.) extract to fibroblast proliferation. The sample was fibroblast cells culture BHK-21 (Baby Hamster Kidney-21). The Mengkudu fruit (Morinda citrifolia L.) extract divide into 3 concentration, 0,2mg/ml; 0,4 mg/ml; and 0,8 mg/m l. These extract applied into fibroblast cell culture and incubated in 24 hours. After incubated, ELIS A reader used to read the result of this experiment. The data were co mpared and examined with Kruskal-Wallis Test end then Z test. Based on the result of the re search above is used to Kr uskal-Walis test, further to Z test for each group, it can calculate the si gnificant differentiate between cell control with extract group 0,2 mg/ml dan extract gr oup 0,4 mg/ml. But it is detectable in significant differentiate with extract group 0,8 mg/ml. T hose verified that increasing doses to be 08 mg/ml the effect s are diminution and indifferent with cell control. Further more it can find the significant dissimiliar between extract group 0,8 mg/ml with 0,4 mg/ml and 0,2 mg/ml in this case. It is prov e that the extract 0,4 mg/ml with 0,2 mg/ml have the similarity boost up effect of prolife ration fibrobast cell. From this research extract 0,4 mg/ml is an optimum doses, it could be find wi thin increasing 0,8 mg/ml doses which is the effect to be decline. Finally it can conclude that ethanol extract of mengkudu fruit (Morinda citrifolia L.) could boost up fibroblast cell proliferation and ethanol extract doses of mengkudu fruit (Morinda citr ifolia L.) as 0,4 mg/ml are optimum could boost up fibroblast cell proliferation.

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