Dhani Agustina, 020413338 (2008) PENGARUH DIABETES MELLITUS YANG TIDAK TERKONTROL TERHADAP TIMBULNYA THRUSH (STUDI PUSTAKA). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Oral candidiasis is a common opportunistic infection of the oral cavity caused by an overgrowth of Candida species, the commonest being Candida albicans. The incidence varies depending on age and certain predisposing factors. There are three broad groupings consisting of acute candidiasis, chronic candidiasis, and angular cheilitis. Risk factors include impaired salivary gland function, drugs, dentures, high carbohydrate diet, and extremes of life, smoking, diabetes mellitus, Cushing's syndrome, malignancies, and immunosuppressive conditions. Management involves taking a history, an examination, and appropriate antifungal treatment with a few requiring samples to be taken for laboratory analysis. In certain high risk groups antifungal prophylaxis reduces the incidence and severity of infections. The prognosis is good in the great majority of cases. Diabetics have elevated glucose levels in oral fluids when blood glucose is high, and these glucose elevations can influence the microbial flora, the composition of bacterial plaque, and the mixture of organisms at the bottoms of the periodontal pockets. Elevated glucose levels may in particular encourage the growth of Candida albicans, the causative agent in thrush, and oral Candida albicans counts have been reported to be higher in diabetics than nondiabetics.

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