ANGGA PRATOMO CAHYADI, 061011109 (2014) PENGARUH EKSTRAK MENIRAN (Phyllanthus niruri Linn.) TERHADAP GAMBARAN HISTOPATOLOGI ILEUM TIKUS PUTIH YANG DIINDUKSI ALKOHOL. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Meniran is one of the traditional medicine plant. It has function as antioxidant, anti-inflammation, antipyretic, antitoxic, and antibacterial. Solution of extract meniran can minimalize damage of organ, for example ileum. The aim of this study was to investigate the positive effect of Phyllanthus niruri Linn extract on histopathological ileum of Rattus norvegicus strain Wistar induced by alcohol. Twenty Rats with an average at 200 grams were induced by alcohol in 25% concentration. Rats on three groups (P2 0.63mg/rats/day, P3 2.7mg/rats/day, and P4 6.26mg/rats/day) induced by Phyllanthus niruri Linn for 7 days then induced by Phyllanthus niruri Linn and alcohol 25% for 14 days, group P0 induced by CMC Na 1 % for 21 days, group P1 induced by alcohol 25% for 14 days. Where P0 was negative control group. Experimental design using a completely Federer design with five replications on each treatment. The data of histopathological changes of ileum was analyzed with Kruskall Wallis test and Z test. The research showed there were no significantly differences of ileum histopathological changes between P0 and P4. P0 showed result of Mean Rank ± SE (6.9b ± 0.04) in edema, (7.1c ± 0.05) in PMN infiltration, (5.9c ± 0.05) in Goblet cell count, and (7.4b ± 0.24) in epitel integrity. Meanwhile, P4 showed result of Mean Rank ± SE (9.0b ± 0.06) in edema, (8.1bc ± 0.06) in PMN infiltration, (10.5bc ± 0.1) in Goblet cell count, and (7.8b ± 0.4) in epitel integrity. It was proved that P4 was most effective dose in reducing histopathological changes.

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