ROSANTI KURNIA DEWI, 060710282
(2011)
HAMBATAN EKSPRESI VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) OLEH EKSTRAK DAUN Gynura procumbens PADA PEMBULUH DARAH MEMBRAN KORIOALANTOIS TELUR AYAM BEREMBRIO.
Skripsi thesis, UNIVERSITAS AIRLANGGA.
Abstract
Angiogenesis is the new blood vessels formation normality and important
on growth and development of individu. Angiogenesis also have contribution to
carcinogenesis or uncontrolled and malignant cancer cell development, become
pathologic condition like inflammatory and infection. The purpose of this research
for knew the effectivities of Gynura procumbens extract on various dose for
inhibition VEGF expression. This research was done to effort cancer progress
inhibition. However, angiogenesis is part of carcinogenesis causes. The Chorio
Allantoic Membrane (CAM) methods was used for this aim. Eggs at the age of
nine days were divided into 6 groups. Group I were negative control of vehicle,
group II were zero treatment: 60 ng bFGF which aplicated into paper dish. The
next four groups were extract of Gynura procumbens that divided in four dose:
60, 75, 90 and 110 μg + bFGF 60 ng which applicated into paper dish. At the
twelve days old, VEGF expression analysis was done which imunohystochemical
method with anti VEGF’s antibody. The result of this research showed that there
was significant different (p<0.05) on give of Gynura procumbens extract to VEGF
expression. The most significant VEGF inhibition by Gynura procumbens extract
with dose 110 μg. The conclusion on this study was Gynura procumbens extract
effective to in
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