MUHAMMAD TAUFIQURRAHMAN, 060610101 (2011) PERBANDINGAN RESPON ANTIBODI DAN PROTEKTIVITAS AYAM SETELAH DIVAKSIN ND AKTIF LENTOGENIK GALUR RIVS2 DAN LENTOGENIK GALUR LA SOTA. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Newcastle Disease is one of important disease in Indonesia because it has high morbidity and mortality. However, it can be prevented by combination of biosecurity and regular vaccination program. By given active vaccine, chicken has more immune respons and protected from the virus, especially if it is given active ND lentogenic strain RIVS2 and lentogenic strain La Sota. This research aims to find out the differences of titer antibody from the chicken which vaccinated by ND active lentogenic strain RIVS2 and strain La Sota vaccine and also to determine the vaccine roles that given to the chicken can have protection from ND virus. This research used 24 chickens and divided into 3 groups, each group consists 8 chickens. P1 group given ND active lentogenic strain RIVS2 vaccine in 2 months old, P2 group given ND active lentogenic strain La Sota in 2 months old and K group as the chicken controller given physiology NaCl in 2 weeks old. Vaccine given done by orally dropped based on the dose for each treatment 0,3 ml/chicken. Blood taking done 2, 4, 6 weeks old. Titer antibody measurements using HI micro-tecnique test and for the result using log2. The research showed active ND lentogenic strain RIVS2 (P1) has different antibody titer with lentogenic strain La Sota (P2), but P2 vaccine, which has higher titer antibody, can cause side effect after vaccination. That’s why it is better to use active ND lentogenic RIVS2 vaccine than lentogenic strain La Sota vaccine for the first vaccination. The result of challenge test (used ND velogenic virus), the mortality of P1 and P2 chicken had the same percentage of 0%, but P2 showed pathology anatomy alterations because of the infection from ND virus. Booster is needed for the implementation of active vaccine, especially if it is used strain RISV2 vaccine, in order to have longer immunity.

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