NURIL LISARAMANIA, 061011003 (2014) PENGARUH PEMBERIAN VITAMIN E (α-tocopherol) TERHADAP JUMLAH HITUNG SEL LEYDIG PADA MENCIT YANG DIPAPAR 2,3,7,8-tetrachlorodibenzo-pdioxin (TCDD). Skripsi thesis, UNIVERSITAS AIRLANGGA.

Preview	Text (abstrak) gdlhub-gdl-s1-2014-ramanianur-32035-4.abstr-t.pdf Download (182kB) | Preview
	Text (fulltext) fulltext.pdf Restricted to Registered users only Download (2MB) | Request a copy

Abstract

The goal of this research was to verify the effect of vitamin E (α-tocopherol) on the number of Leydig cell in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Five experimental groups of a combination of TCDD and vitamin E were designed as follows: 0 ng/kg/d and 0 mg/kg/d (P0), 100 ng/kg/d and 0 mg/kg/d (P1), 100 ng/kg/d and 11 mg/kg/d (P2), 100 ng/kg/d and 20 mg/kg/d (P3), and 100 ng/kg/d and 37 mg/kg/d (P4) respectively. Vitamin E and TCDD were given by oral gavage for 9 days. The results demonstrated that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) could have any effect on male germ cells especially Leydig cell. TCDD decreased the number of Leydig cell in intertitial seminiferous tubule. Vitamin E (α-tocopherol), which is knownly well to have potential as an antioxidant, to protect the demage to the body caused by exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Best dose of vitamin E is 37 mg/kg/d increased the number of Leydig cell as well as negative control.

Actions (login required)

View Item