SEPTIAN PRIATAMA, 060911056 (2014) POTENSI MENIRAN(Phyllantus niruri L) DALAM MENINGKATKAN KADAR ALBUMIN TIKUS PUTIH (Rattus norvegicus) DENGAN PEMBERIAN PARACETAMOL DOSIS TOKSIK. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

The purpose of this study was to determine the potential of Meniran (Phyllanthus niruri L.) against serum albumin induced by paracetamol on white rat. Twenty wistar rats, body weight 150-200 g. two months old were used in this study. Samples were randomly divided into five treatments P0 as a negatif control, P1 as positive control, P2, P3, and P4. Negative controls received distilled water for ten days. Positive controls (P1) received paracetamol with dose 216 mg / kg total weight, P2 received paracetamol with dose 216 mg / kg total weight and meniran with dose 0.66 mg / kg total weight, P3 received paracetamol with dose 216 mg / kg total weight and meniran with dose 3.78 mg / kg total weight, and P4 received paracetamol with dose 216 mg / kg total weight and meniran with dose 6.63 mg / kg total weight. Paracetamol and meniran were given respectively for five days orally. Rats were euthanasied on the day 17 blood were collected intracardially. Data of total serum albumin levels were analysed using ANOVA followed by the Honest Significant Difference test (HSD) with a significant level of 5% to determine the different treatments. The results of this study was the serum levels of total albumin rats no significant difference in each treatment.

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