Vina Avianie, 060610013 (2012) PENGARUH PEMBERIAN EKSTRAK MENIRAN (Phyllanthus niruri Linn) TERHADAP KADAR NITROGEN UREA DARAH (BUN) DAN KREATININ SERUM TIKUS PUTIH ( Rattus norvegicus) JANTAN YANG MENGALAMI GANGGUAN FUNGSI GINJAL. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

There are a lot of useful content in meniran (Phyllanthus niruri L). The form of flavonoids, Lignans, Damar, Tanin, Potassium, and Vitamin C. Flavonoids act as antioxidants. The purpose of this study was to determine the effect of meniran extracts on blood urea nitrogen levels and serum creatinine of impaired renal function male rats (Rattus norvegicus). Study sample was 24 mice age 2-3 months and wistar strain. Samples were randomly divided into 4 treatment of K-, K +, P1 and P2, respectively - each divided into six groups of rats in the adaptation for seven days. The treatments were given on the 8th days. Negative controls received distilled water for ten days. Positive controls received acetaminophen with doses 4800 mg /KgBB. P1 received acetaminophen with doses 4800 mg/KgBB and meniran with doses 100 mg/KgBB. P2 received acetaminophen with doses 4800 mg/KgBB and meniran with doses 200 mg/KgBB. Acetaminophen and meniran were respectively for five days per oral. Rats were euthanasied on the 17th day to have blood drawn intracardially. Data of Blood urea nitrogen levels were analysed using ANOVA followed by the Smallest Real Differences Test (LSD) with a significant level of 5% to determine the different treatments. Data of Serum creatinine were analysed using showed Kruskal - Wallis Test. The results of this study there were marked difference on Blood Urea Nitrogen levels (BUN)between the groups negative with P2 and P1 with P2. There were no significant difference on serum creatinine levels in each treatment. It shows meniran with renal function.

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