ANGGRAENI EKA HANDOKO, 061011100 (2014) POLA WAKTU PEMBERIAN EKSTRAK RIMPANG KUNYIT PUTIH (Curcuma zedoaria) TERHADAP JUMLAH NODUL PARU MENCIT(Mus musculus) YANG DIINDUKSI BENZO(α)PYRENE. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

This experiment was aimed to investigate the influence of Curcuma zedoaria ethanol extract on the growth of benzo(α)pyrene-induced lung tumor in male mice. New born miced were induced with 0,2 μmol, 0,4 μmol, and 0,6 μmol benzo(α)pyrene intraperitoneally at day 1, 8, and 15 after born. On day 21 after born, the male mice were distributed into 5 groups. Group 1 was B(α)P induced tumor positive control and group 2 was treat with DMSO (solvent). Mice were sacrificed at 4 month age, and lung were collected for examination of tumor nodules macroscopic. Group 3, 4 and 5 were treated with Curcuma zedoaria Rosc. ethanol extract consecutively 500 mg/kgBW. Intensity of carcinogenicity was expressed as number of tumor bearing mice in each group, and number of tumor nodules per mouse lung. From the result it was concluded that Curcuma zedoaria Rosc. ethanol extract on day 20th, every 2 times a week until 8 weeks can inhibit the growth of lung tumor in male mice up to 61,29%.

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