ANTON LAMBAN, 061011247 (2014) HISTOPATHOLOGY OF INTESTINE AND UTERINE OF MICE (Mus musculus) POST VACCINATION AND CHALLENGE TEST USING H5N1 AVIAN INFLUENZA VIRUS. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Avian influenza virus is able to multiply in the respiratory apparatus, digestive, nervous system, and blood circulation so as to attack and damage all organs and vaccination is an effective way to against Avian influenza virus. This research aimed to find out the histopathological appearance of the intestine and uterine of mice (Mus musculus) post vaccination and challenge test using H5N1 Avian influenza virus. The study was conducted from March to July 2014 at Avian Influenza Research Center (AIRC) Universitas Airlangga Surabaya, Departement of Pathology, Faculty of Veterinary Medicine, Universitas Airlangga. Twenty-five female mice (Mus musculus) aged 6-8 weeks were divided into five groups (P1, P2, P3, P4, and P5). Each group were consists of 5 mice. P1 – P4 were treated with different reverse genetic vaccine and on day 14, the mice got injected with the same concentration of the vaccine (booster). Meanwhile mice in P5 were treated only with PBS. After vaccination, the mice get challenge test using H5N1 Avian influenza virus. Intestine and uterine were stained with Hematoxylin Eosin then examinated by light microscope.The intestine examination result revealed that there were villi erosion in P1 and P5 and congestion in P5. The uterine examination result revealed that there were haemorrhage and congestion in P5.

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