Pritta Aprilina Ardiansari, 060413367 (2008) EFEK TOKSISITAS AKUT EKSTRAK DAUN MINDI (Melia azadirachta L.) TERHADAP GAMBARAN HISTOPATOLOGI HEPAR MENCIT (Mus musculus). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

This research has been done to know the effect of acute toxicity of mindi’s leaf (Melia azadirachta L.) extraction to liver histopatology description of mice (Mus musculus). 32 mices age three month weight 25 grams, devided into two research 24 hours and 14 days, both devided into four treatment and four replicates. P1 as a control of intra peritoneal, P2 as a control of per oral, P3 as a treatment of intra peritoneal, and P4 as a treatment of per oral. The treatments were given once a day until days 14. The research of histopatology zooming 400x. Measurement of the liver change were considered insignificantly different at α<0,05. The result show that mindi’s leaf (Melia azadirachta L.) extract 5,57 mg/25 g of body weight caused a congestion, degeneration, and necrosis insignificantly case. The conclution is mindi’s leaf extract applied didn’t cause a significant disturbance on liver and including a practically non toxic of traditional medicine.

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