ARINA HAYATI, 051111050 (2016) PENGARUH EKSTRAK DAUN Vitex trifolia TERHADAP PERTUMBUHAN VIRUS INFLUENZA A SUBTIPE H1N1 PANDEMIK 2009. Skripsi thesis, UNIVERSITAS AIRLANGGA.
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Abstract
In 1918 there was an A H1N1 influenza epidemic that was known as the Spanish Flu. That epidemic caused the death of 20 million people. In mid-April 2009 there was another epidemic of the same virus but of a different strain. In March 2015 31.156 people were reported positive H1N1 in India and 1.841 people died. a resistance to H1N1 antivirus has occurred, because of that, a new antivirus is need. In this experiment five concentrations of the extract of Vitex trifolia leaf is used for a toxicity experiment in an embryonated chicken egg (ECE). After the toxicity experiment is done, an activity experiment is also done using the concentrations that do not cause toxicity to ECE. The activity test used H1N1 pandemic 2009 virus with A/Indonesia/UNAIR-367/2010A strain. The virus and the extract are injected simultaneously into the allantoic space of ECE. After that the titer of the virus is calculated with a hemaglutinin test, after the ECE have been incubated for 72 hours at 370C. The result of the experiment showed the concentration of the chosen samples have a lower titer of virus compared to the control. After the HA test, docking is also done to one of the compounds in the Vitrex trifolia leaf, Vitrexin. PBD-ID: 3B7E (neuraminidase complex with zanamivir) is used. The results of the docking is Vitexin rerank score is almost the same as Zanamivir and three types of Arginine binded.
| Item Type: | Thesis (Skripsi) | ||||||
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| Additional Information: | KKB KK-2 FF.FT 02/16 Hay p | ||||||
| Uncontrolled Keywords: | H1N1 virus Pandemic 2009, Vitex trifolia, hemaglutinatinin test, docking | ||||||
| Subjects: | R Medicine > RS Pharmacy and materia medica | ||||||
| Divisions: | 05. Fakultas Farmasi > Farmakognosi Fitokimia | ||||||
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| Depositing User: | Unnamed user with email indah.fatma@staf.unair.ac.id | ||||||
| Date Deposited: | 22 Apr 2016 01:57 | ||||||
| Last Modified: | 22 Apr 2016 01:59 | ||||||
| URI: | http://repository.unair.ac.id/id/eprint/29712 | ||||||
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