Sumarni, NIM010981332 (2015) KORELASI ANTARA ARTERIAL STIFFNESS MENGGUNAKAN CARDIO-ANKLE VASCULAR INDEX DENGAN ATEROSKLEROSIS MENGGUNAKAN CAROTID INTIMA-MEDIA THICKNESS PADA PENDERITA ANGINA STABIL. Thesis thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Chronic stable angina is the initial manifestation of schemic heart disease in approximately one half of patients. Stable anatomical atherosclerotic may act as underlying pathogenesis. Atherosclerosis is a pathological condition of the intima which lead to arterial stiffness. Carotid-intima media thickness (CIMT) measures structural changes in the arterial and is a well-established marker of (subclinical) atherosclerosis. Recently, arterial stiffness parameter called cardio-ankle vascular index (CAVI) has been developed. Objective: To evaluate the correlation between CAVI and CIMT in stable angina patients. Methods: A cross-sectional study was conducted in 35 patients with stable angina of cardiology outpatient clinic of Dr. Soetomo Hospital, Surabaya underwent CIMT and CAVI measurement. CIMT was evaluated by ultrasonography. CAVI was measured using an automatic vascular screening system. Result: Study subjects were 71,4% males and 28,6% females, with mean age 57,7±8,00 years old. Proportion of dyslipidemia was 57,1%, obesity 45,7%, hypertension 42,9%, smoking 42,9, diabetes mellitus 20,0% and family history of CAD 5,7%. CIMT measurement shows subjects with low risk CVD 37,1%%, moderate risk 25,8% and high risk 37,1%. CAVI measurement shows subjects with normal, borderline, and abnormal were 62,9%, 25,7%, 11,4%. Using pearson’s correlation showed CAVI significantly moderate correlated with CIMT maximum and CIMT average (r 0.547, p 0.001;r 0.535, p 0.001) Conclusion: CAVI modestly correlated with CIMT in stable angina patients.

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