HERNIYATI, NIM011217017326 (2016) MEKANISME PERGERAKAN GIGI ORTODONTI DAN PROSES REMODELING TULANG ALVEOLAR YANG DIINDUKSI GAYA MEKANIS ORTODONTI AKIBAT PEMBERIAN SEDUHAN KOPI (Studi Eksperimental Pada Hewan Model). Disertasi thesis, UNIVERSITAS AIRLANGGA.
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Abstract
Objective: To experimentally test the mechanism of orthodontic tooth movement and alveolar bone remodeling process induced with orthodontic mechanical force resulted from administration of coffee steeping. Material and methods: The research method used was experimental laboratories, 24 rats , were divided into 3 groups. Group A: the rats were applied with OMF and 2 ml of distilled water, group B: OMF + coffee steeping at 20 mg/100 g of body weight in 2 ml of distilled water, and group C : OMF + caffeine of 1,37 mg 100 g of body weight in 2 ml of distilled water. OMF was conducted by applying ligature wires of 0.20 mm in diameter on the molar-1 (M-1) of right permanent maxilla and both incisivus of maxilla. Subsequently, the M-1 of right maxilla was moved to mesial with Ni-Ti orthodontic closed coil spring. Observations were made to take GCF at the mesio- and disto- palatal M-1 of right maxilla and then determined the levels of RANKL, OPG, VEGF, and TGF-β1 using ELISA method. Histological examination was conducted to calculate the number of osteoblasts, osteoclasts, and bone island. Increased tooth movement in the rats was measured resulted from X-ray photograph Results: showed that the administration of coffee steeping proved effectively increased the levels of RANKL, OPG, VEGF, and TGF-β1 in both compression area and tension area greater compaired with that administered only with pure caffeine, and those which were not administered with coffee steeping and pure caffeine (p <0.05). The administration of coffee steeping improved the movement of M1 of right maxilla compared to those not administrated with coffee steeping or caffeine (p <0.05). Conclusions: the coffee steeping administration increased orthodontic tooth movement and alveolar bone remodeling.
| Item Type: | Thesis (Disertasi) | |||||||||
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| Additional Information: | KKA KK DIS.K.05/16 Her m | |||||||||
| Uncontrolled Keywords: | RANKL, OPG, VEGF, TGF-β1, Coffee, OMF | |||||||||
| Subjects: | R Medicine > RK Dentistry > RK520-528 Orthodontics | |||||||||
| Divisions: | 09. Sekolah Pasca Sarjana > Ilmu Kedokteran | |||||||||
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| Depositing User: | Guruh Haris Raputra, S.Sos., M.M. '- | |||||||||
| Date Deposited: | 02 Jun 2016 00:08 | |||||||||
| Last Modified: | 02 Jun 2016 00:08 | |||||||||
| URI: | http://repository.unair.ac.id/id/eprint/30844 | |||||||||
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