SULISTIAWATI, 091070123 (2014) FAKTOR RISIKO INFEKSI DENGUE MENJADI PARAH BERDASARKAN HLA-A*24, GOLONGAN DARAH ABO, INDEKS MASSA TUBUH DAN PERILAKU PENCEGAHANNYA Studi pada penderita DBD/DD keturunan Jawa,Cina dan keturunan lain di Surabaya. Disertasi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

This was a cross-sectional study with consecutive sampling of DHF/DF patients aged over 12 years hospitalized in three private hospitals in Surabaya. Data collection was conducted from March 20, 2013 to May 20, 2013 with a sample size of 95 patients. The results showed that Chinese was the ethnic group with the most severe dengue infection profiles assessed using the criteria of WHO (82.1%) and bleeding symptom, highest haemoglobine concentration (15.62 ± 1.70 g/dl), highest PCV concentration (44.90 ± 4.23%) and lowest platelet counts (31.42 ± 22.05 x 103 #956;l), however, the lowest leukocyte counts were of other ethnicities (2.12 ± 1.53 x 103 #956;l). The results of logistic regressions showed the influence of male sex (p: 0.000), Chinese ethnicity (p: 0.038), and less drinking water consumption (p: 0.017) on dengue infection severity based on Hb increase hemoconcentration. Male sex (p: 0.000) and obesity (p: 0.020) influenced the severity of dengue infection based on PCV increase hemoconcentration. Conclusion: Chinese was the ethnic with mostly at risk of severe clinical and laboratory symptoms when infected with dengue virus. Dengue infection among males, Chinese, and less water drinking consumption were more likely to become severe Dengue infection based on Hb increase hemoconcentration. Dengue infection among males and obese were likely to become severe Dengue infection based on PCV increase hemoconcentration

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