ANANG TRIBOWO, 090515741 D (2011) PATOGENESIS ULKUS KORNEA PROGRESIF DAN NON PROGRESIF MELALUI STUDI EKSPRESI : IL-6, IL-8, MMP-8 DAN TGF-β. Disertasi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

The pathogenesis of progressive and non progressive corneal ulcer through expression studies: IL-6, IL-8, MMP-8 and TGF- . Background : Corneal ulcer is the inflammation of the cornea with suppurative infiltrate which usually causes perforation and ends with blindness. Many medicines had developed to provide an adequate therapy, however in real the damaging process of the cornea still occurs. Purpose: To explore the pathogenesis of the progressivity of corneal ulcer which is caused by infection. Method: Samples had taken fulfil the inclusion criteria (total sample) followed in this research, tissue close to the ulcer area was taken using Kimura Spatula and fixed to evaluated as immunohistochemical. Every particles which touched the cornea would cause the release of pro inflammation cytokines which are IL-6, IL-8, TNF- which boosts the neutrophils and Furthermore MMP-8. In the healing process, The TGF-beta which is produced by macrophage cells will stimulate the formation of collagen tissues. All four of the variables(IL-6, IL-8, MMP-8 and TGF-beta undergoes statistical analysis, NPar test, one sample Kolmogorov-Smirnov test, and Chi- Square test. Result : There was a difference of IL-6 significantly p;0.041, IL-8 had no significant difference, MMP-8 and TGF-beta had no differences also. The samples were homogeny. The location of the ulcer was associated by its progress, differ significantly between central and para central. Conclusion: The role of cytokine in the progress of corneal ulcer had no meaning, it was suspected that the progress of corneal ulcer was very much correlated with the corneal physical condition itself.

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