M. YULIANTO LISTIAWAN, 090710142 D (2011) PERBANDINGAN EKSPRESI TLR2/1,NF- #1082;B p105/50, NF- #1082;B p65 DAN TNF- PADA MAKROFAG PENDERITA ERITEMA NODUSUM LEPROSUM DENGAN KUSTA MULTIBASILER SEBAGAI TANDA AKTIVITAS KEKEBALAN ALAMIAH. Disertasi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Backgroud : Erythema nodusum leprosum (ENL) is one of the complication in Multibacillary ( MB) leprosy. The cause , mechanism, and treatment of ENL remain highly problematic.The studies have identified possible evidence involvement of innate immune system. Objective : To compare the expression of TLR2/1, NF-кBp105/p50, NF- кBp65, TNF-α are significant different in ENL patient than in MB patient without ENL as marker of involvement of innate immune system. Material & Method : A cross sectional study design has been performed using 21 ENL and 21 MB leprosy patient without ENL in Out Patient Clinic Dr Soetomo Hospital, on February 2010 until December 2010. For all group were imunohistochemical staining method to determine the expression in dermis macrophages cell using specific monoclonal antibody for TLR2/1, NF-кBp105/p50, NF-кBp65 and TNF-α. Statistical analysis was performed using Mann-Whitney U test. Result : The finding confirmed a very significant different expression of TLR2/1, NF-кBp105/p50, NF-кBp65 and TNF-α in dermis macrophages between ENL group and MB leprosy without ENL group. Conclusion : The innate immunity were activated during ENL reaction, as shown by strong higher expression in TLR 2/1, NF-кB p105/p50, NF-кB p65.

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