YULIA FARIDA YAHYA (2011) EKSPRESI ; CATENIN DAN ;4 INTEGRIN PADA KARSINOMA SEL BASAL AGRESIF DAN NON AGRESIF. Disertasi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Background : Aggressive basal cell carcinoma (BCC) is a high risk type of BCC which frequently locally aggressive and has been associated with greater subclinical depth of extension and a greater rate of local recurrence in BCC with aggressive histopathologic variants. Until now, the role of molecular biology marker in predicting the aggressiveness of BCC is not clear. Purpose: To determine the expression of catenin and 4 integrin in the aggressiveness of BCC, to analyze the expression of catenin and 4 integrin in aggressive BCC compare with non aggressive BCC. Methods : This research was`done by observational with cross sectional study from 58 primary BCC patients who visited Skin Surgery and Tumor Division Outpatient clinic M Hoesin General Hospital Palembang during periode Januari 2008-December 2009 was involved. Characteristic of the primary BCC patient results were recorded. Skin biopsy from primary BCC lesion were taken and Histopathological examination was performed for detection BCC subtype and Immunohistochemistry test for detection of catenin and 4 integrin was performed. The level of catenin and 4 integrin were measured quantitatively. Statistically data were analyzed by using the chi-square, independent sample t test, and multiple logistic regression Result: The results of this study showed in primary BCC there was a significant correlation between expression of catenin and 4 integrin in aggressive and non aggressive of BCC (p <0,05), the expression of catenin (t = -5006, p< 0,05) and 4 integrin (t = -3.714, p< 0.05) was significant greater in aggressive than non aggressive of BCC, there was also significant correlation between expression of catenin and 4 integrin in aggressiveness of BCC ( catenin p #8804; 0.002, OR=1,154; 4 integrin p #8804; 0.004, OR=1,067), which means the influence of catenin has a strong significant 1,154 time and 4 integrin has a strong significant 1,067 time in aggressiveness of BCC. Conclusion : The expression of catenin and 4 integrin were significantly greater in aggressive than non aggressive BCC, and there were significant correlation of catenin and 4 integrin in aggressiveness of BCC with the type of histopathology of BCC based on growth pattern

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