JONI ANWAR, 090315289 D (2013) PENGARUH ASAP ROKOK TERHADAP GSH, MMP-8 DAN MMP-9 PADA PATOGENESIS EMFISEMA. Disertasi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Background : Emphysema is a condition of lung characterized by abnormal and permanent enlargement of distal airspaces from terminal bronchiole, accompanied by destruction of their walls, and without obvious fibrosis. The aims of this study is to know the impacts of cigarette smoke in pathogenesis of emphysema. A cross-sectional analytical study was conducted to cigarette smokers with emphysema as the study group and cigarette smokers without emphysema as the control group. Methods : The study variables were GSH concentration, MMP-8 and MMP-9 activity. The statistical analyses comprised of homogeneity, normality and independent T test. All participants are men, 18 patients are cigarette smokers with emphysema as a the study group and 19 cigarette smokers without emphysema as a the control group. The examination of GSH, MMP-8 and MMP-9 were using ELISA method. Results : It was found that the decrease concentration of GSH (12.37 ± 4.10) #956;M in the study group was lower than the control group (16.28 ± 9.47) #956;M and the difference was not significant (p>0.05). There was a significant increase of MMP-8 activity (1024.87 ± 488.49) ng/ml in the study group in comparison (263.50 ± 60.45) ng/ml with the control group (p<0.05). There was an increase activity of MMP-9 ( 2080.47 ± 1712.94) ng/ml in comparison with the control group (749.92 ± 331.64) ng/ml, the difference was significant (p<0.05). Conclusion : There is not significant decreased of the concentration of GSH and there are significant increased of MMP-8 and MMP-9 activity which degrade most of elastin in matrix extracellular as the cause lung emphysema

Item Type:	Thesis (Disertasi)
Additional Information:	KKA KK Dis K04/13 Anw p
Uncontrolled Keywords:	Emphysema, GSH, MMP-8 and MMP-9
Subjects:	R Medicine > R Medicine (General) > R735-854 Medical education. Medical schools. Research
Divisions:	09. Sekolah Pasca Sarjana > Ilmu Kedokteran
Creators:	Creators NIM JONI ANWAR, 090315289 D UNSPECIFIED
Contributors:	Contribution Name NIDN / NIDK Thesis advisor Muhammad Amin, Prof. Dr., dr., Sp.P(K) UNSPECIFIED Thesis advisor Soetjipto, Prof., dr., MS., Ph.D UNSPECIFIED Thesis advisor Retno Handajani, Prof., dr.,MS.,Ph.D UNSPECIFIED
Depositing User:	mat sjafi'i
Date Deposited:	30 Aug 2016 07:08
Last Modified:	30 Aug 2016 07:08
URI:	http://repository.unair.ac.id/id/eprint/32120
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