MOCHAMAD LAZUARDI, 099813156 D (2004) UJI TRIPANOSIDAL DIMINAZEN ASETURAT : Perancangan regimen dosis efektif dan pemeriksaan toksisitas akibat pemberian obat berulang pada kambing Peranakan Etawa penderita tripanosomiasis. Disertasi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Cases of trypanosomiasis in Indonesian animal husbandries has been a problem for the Indonesian livestock society since 1897. The major problem in controlling trypanosomiasis was in the use of available medicines. This problem was exascerbated by the fact that suramin the main medicine used was not produced again except for research purposes. The Indonesian Government recommended other trypanocide agents (isometamidium chloride and diminazene aceturate) wich were readily available within Indonesia for the treatment of trypanosomiasis. However research had shown that isometamidium chloride was particularly ineffective unless used in exceptionally high doses. Because of these ongoing problems it was decided that more research was needed both into the disease and the dose level (of diminazene aceturate) to obtain a new dosage regimen with trypanocide activities and prevent toxic side effects. The experimental research used three design they were : pm, true and quasi experimental. The parasites used in the research were of the Trypanosoma evansi Bangkalan Isolates. The subjects of the research were Etawa breed goats sourced from the Surabaya area. To determine the concentration of diminazene aceturate, goat plasma was screened using reverse-phase high performance liquid chromatography, with ion pairing. To examine the parasites within the blood samples were examined using biological assay and card aglutination base on common surface antigen. To discover the toxic effect of medicines used in the research, a screen of ante mortem toxic symphtome was used continuously with liver and renal histopathology techniques. The research indicated that the new dosage regimen should be used as follows ; (a) loading dose 10.44 mg/kg body weight, (b) maintenance dose 7 mg/kg body weight. (c) After the initial dose of 10,44 mg/kg bw fourth additional maintenance dose should be administered at 31 minute intervals_ This formula will work effectivly against Trypanosoma evansi Bangkalan Isolates and safety for using (P<0.05). The length of time the drug concentration exceeds the therapeutic concentration level obtained at > 24 hours (p>0.05). The results of the test confirm that the new dosage regimen may be used as an alternative model when giving diminazen aceturate as a remedy against ruminan trypanosomiasis.

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