Pagan Pambudi, 090415421M (2006) PERBANDINGAN EFEKTIVITAS ANTIPSIKOTIK TIPIKAL DAN ATIPIKAL PADA PENGURANGAN GEJALA PUTUS OBAT MORFIN : Suatu Penelitian Eksperimental Laboratorium. Thesis thesis, UNIVERSITAS AIRLANGGA.

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Abstract

This study was aimed to elaborate the effect of atypical and typical antipsychotics chlorpromazin (5,10, 30 mg/kg ), haloperidol (l, 4, 10 mg/kg) clozapin (10,15, 20 mg/kg) and risperidon (1,4, 8 mg/kg) in reducing morphine withdrawal syndromes. Body weight loss during morphine pre treatment, diarrhea incidence, abdominal constriction and wet dog shakes was not prevented by all antipsychotics. Clozapin (10, 20 mg/Kg), risperidon (1,4 mg/kg), chlorpromazin (10, 30 mg/kg) could decrease swallowing movement. Exept clozapin 20 mg/kg all antipsychotics attenuated erection incidence. Risperidone (1,4,8 mg/kg) and chlorpromazine 30 mg/kg significantly attenuate `attempt to escape behaviour. Body weight loss during morphine withdrawal that measured one hour after naloxone injection.was prevented by both typical and atypical except chlorpromazine 5 mg/kg and haloperidol (1,4 mg/kg) and they both could decrease morphine withdrawal syndrom score according Gellertz Holtzman withdrawal rating score. In conclusion, both class of the antipsychotics reduced some of morphine withdrawal signs such as; erection, swallowing movement, and weight loss. Total Gellertz Holtzman rating score decreased to the range of 33,3% - 61,1 %. In addition, (RIS) risperidone reduced hyperlocomotion better than other antipsychotics used in this study, where as (CLO) Clozapin and (CPZ) chlorpromazine resulted in better response in reducing wet dog shakes effect than haloperidol (HAL) and risperidone (RIS).

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