ERNA SULISTYANI, 099913297M
(2002)
PENINGKATAN APOPTOSIS DAN EKSPRESI p53 PADA SEL ASINAR KELENJAR PAROTIS SEBAGAI DASAR PATOGENESIS XEROSTOMIA PADA TERAPI RADIASI.
Thesis thesis, UNIVERSITAS AIRLANGGA.
Abstract
PURPOSE: to investigate the effects of ionizing radiation to p53 expression and apoptosis of acini cells of mice salivary gland. MATERIAL AND METHOD: Male BALB/c mice were irradiated with 50 rad of y ray. Irradiation was given to whole body. p53 and apoptosis were examined after 24 hour and 48 hour after exposure. As control groups, mice were irradiated with zero rad of y ray and salivary glands were examined at same time. Examination of p53 was by immunohistochemistry and apoptosis was by TUNEL assay. RESULTS: Expression of p53 in treatment group, elevated 7 folds at 24 hours after exposure and 3 folds at 48 after exposure, in comparison with control groups. Cells undergo apoptosis in treatment group elevated 9 folds at 24 hours after exposure and decreased until 3 folds in comparison with control groups at 48 after exposure.
Item Type: |
Thesis
(Thesis)
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Additional Information: |
KKA KK TKD 01/02 Sul p |
Uncontrolled Keywords: |
Apoptosis, salivary gland, p53, and ionizing radiation |
Subjects: |
R Medicine |
Divisions: |
09. Sekolah Pasca Sarjana > Ilmu Kedokteran Dasar |
Creators: |
Creators | NIM |
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ERNA SULISTYANI, 099913297M | UNSPECIFIED |
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Contributors: |
Contribution | Name | NIDN / NIDK |
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Thesis advisor | Putra, Suhartono Taat | UNSPECIFIED |
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Depositing User: |
Fahimatun Nafisa Nafisa
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Date Deposited: |
2016 |
Last Modified: |
02 Jul 2017 19:02 |
URI: |
http://repository.unair.ac.id/id/eprint/35726 |
Sosial Share: |
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