ERNA SULISTYANI, 099913297M (2002) PENINGKATAN APOPTOSIS DAN EKSPRESI p53 PADA SEL ASINAR KELENJAR PAROTIS SEBAGAI DASAR PATOGENESIS XEROSTOMIA PADA TERAPI RADIASI. Thesis thesis, UNIVERSITAS AIRLANGGA.

Preview	Text (ABSTRAK) ABSTRAK.pdf Download (206kB) | Preview
Preview	Text (Fulltext) 35726.pdf Download (2MB) | Preview

Abstract

PURPOSE: to investigate the effects of ionizing radiation to p53 expression and apoptosis of acini cells of mice salivary gland. MATERIAL AND METHOD: Male BALB/c mice were irradiated with 50 rad of y ray. Irradiation was given to whole body. p53 and apoptosis were examined after 24 hour and 48 hour after exposure. As control groups, mice were irradiated with zero rad of y ray and salivary glands were examined at same time. Examination of p53 was by immunohistochemistry and apoptosis was by TUNEL assay. RESULTS: Expression of p53 in treatment group, elevated 7 folds at 24 hours after exposure and 3 folds at 48 after exposure, in comparison with control groups. Cells undergo apoptosis in treatment group elevated 9 folds at 24 hours after exposure and decreased until 3 folds in comparison with control groups at 48 after exposure.

Actions (login required)

View Item