HERIYADI MANAN (2011) ANALISIS INTERLEUKIN-1, INTERLEUKIN-6, MATRIX METALLOPROTEINASE-13, TUMOR NECROSIS FACTOR-, PROSTAGLANDIN DAN RESEPTOR PROGESTERON PADA ENDOMETRIUM AKSEPTOR ALAT KONTRASEPSI DALAM RAHIM CuT 380ª. Disertasi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Menstrual pattern disorder such as heavy and prolonged cyclic menstrual bleeding in contraceptive IUCD CuT 380A acceptors in which underlying factors has not been completely yet understood. Presumably, There is a change in endometrial line, cytokine expression and activity and protease in IUCD CuT 380A acceptors endometrium. Objective: the objective of this study is to analyze the expression of IL-1, IL-6, TNF-, MMP-13, prostaglandin, progesterone in the endometrium of IUCD CuT 380A acceptors and normal women. Results: according to study analysis found that IL-1 of bleeding IUCD CuT 380A acceptors was higher than control group (p=0,000). In non-bleeding IUCD CuT 380A suggested no significant difference compared to non-bleeding control group (p=0,067). IL-6 of bleeding IUCD CuT 380A acceptors was higher than non-bleeding IUCD CuT 380A acceptors (p=0,000). IL-6 of non-bleeding IUCD CuT 380A acceptors is not different from bleeding-control (0,594). TNF- of IUCD CuT 380A acceptors was higher than control group (p=0.000). In non-bleeding IUCD CuT 380A acceptors suggested no difference in TNF- of non-bleeding control group (p=0.406). MMP-13 of bleeding IUCD CuT 380A acceptors was higher than control group (p=0,000). In non-bleeding IUCD CuT 380A acceptors, MMP was not different from bleeding control group (p=0,868). Prostaglandin of bleeding IUCD CuT 380A acceptors was higher than control group, in non-bleeding IUCD CuT 380A acceptors suggested that there was mean difference of prostaglandin in control group (0,009). Progesterone receptor in bleeding IUCD CuT 380A acceptors was lower than control (p=0,017), in IUCD CuT 380A acceptors was not different from bleeding IUCD CuT 380A acceptors group (p=1.000). Conclusion: it is suggested that the increased expression of IL-1, IL-6, TNF-, MMP-13, prostaglandin, in bleeding IUCD CuT 380A acceptors. There was not difference in expression of progesterone receptor in either bleeding or non-bleeding IUCD CuT 380A acceptors. Increased IL-6 contribute to the occurrence of menorrhagia in IUCD acceptors CuT 380A. Endometrial progesterone receptor is a protective factor against the occurrence of menorrhagia.

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