Diah Prabawati Retnani (2012) PENGARUH EKSPRESI VASCULAR ENDOTHELIAL GROWTH FACTOR ( VEGF ) TERHADAP PERTUMBUHAN TUMOR DAN EDEMA PERITUMORAL PADA ASTROCYTOMA. Other thesis, UNIVERSITAS AIRLANGGA.

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Abstract

BACKGROUND : Astrocytoma is a glial tumor that derived from astrocyte cells with various tumor size, histopathologic grading and peritumoral edema. Angiogenesis plays role in tumor grading, tumor size and formation of peritumoral edema. VEGF is needed for proliferation, survival, migration of endothel cell and vascular permiability. The role of VEGF to regulate peritumoral edema in brain tumor is still debated. This study was conducted to determine the association between VEGF expression with tumor size, histopathologic grading and peritumoral edema of astrocytoma. METHOD : Pathology archives of grade II, III and IV astrocytomas at Dr Soetomo hospital Surabaya between Januari 2009 – Januari 2012 were retrieved. Thirty cases of astrocytomas that fulfilled the conclusion criteria were stained with VEGF rabbit monoclonal antibody (clone EP1176Y). Association between VEGF expression with tumor size and histopathologic grading were analyzed using Spearman correlation test. Association between VEGF expression and peritumoral edema was analyzed with contigency coefficient test. RESULT : There were 29 of 30 cases of astrocytoma showing VEGF expression. Of 29 cases, 13 cases were grade IV astrocytoma, 22 cases had tumor size of more than 2 cm and 17 cases showing peritumoral edema. Statistical analyzis revealed that VEGF had a significant association with histopathologic grading (p=0,023; rs= 0,413) and tumor size (p=0,005; rs= 0,499). In contrast, VEGF expression had no significant assoiation with peritumoral edema (p=0,273). CONCLUSION : This study revealed that VEGF plays role in increasing histopathologic grading and tumor size in astrocytoma but its role in peritumoral edema is not significant.

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