LUNARDHI SUSANTO, NIM011214653004 (2014) PENGARUH TERAPI OKSIGEN HIPERBARIK TERHADAP EKSPRESI NF-κB DAN INTEGRIN V3 PADA ENDOMETRIUM TIKUS BETINA(Rattus novergicus strain Wistar) SAAT JENDELA IMPLANTASI. Thesis thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Embryo implantation is an absolute requirement for an embryo to keep their growth. There are many successes inways to improve the embryo quality, especially in the in assisted reproductive technology. In contrast, endometrial receptivity has failed to benefit from parallel improvement of the embryo. Here, the researcher investigates the expression pattern of NF-κB and V3 integrin post hyperbaric oxygen treatment. The design of this experiment was pre-posttest control groups design. The animals were divided into two groups (either ontain six animals), control and treatment groups. The control group got 1 ATA for 90 minutes for ten sessions, started in the first day of the estrous cycle and the treatment group got 2.4 ATA, three times for 30 minutes with air breaks for 5 minutes, started in the first day of the estrous cycle. After the treatments were done,all animals were rested for one estrous cycle. In the next first day of estrous cycle, they mated with vasectomized mouse. The next day, all of animalswere checked for vaginal plug. They which negative were droppedout; the positivewas said in the day one of pseudo pregnancy. In the fourth day of pseudo pregnancy,hysterectomy was done then checked for implanted embryo. If they were positive, it dropped out. The negative was checked for the expression of NF-κB and V3 integrin with immunohistochemistry method. The results of NF-κB examination were 1.033 ± 1.2853 for control group and 3.233 ± 3.1111 for treatment group (p < 0.05).The expressions of V3 integrin were 0.83 ± 1.1103, for control group and 6.53 ±1.64216 for treatment group (p=0.003). It can be concluded that hyperbaric oxygen treatment affects the window of implantation in the female mouse (Rattusnovergicus, Wistar�s strain).

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