Sintesis dan uji aktivitas antikanker senyawa 1-(2-klorobenzoiloksi)urea dan 1-(4-klorobenzoiloksi)urea

Suko Hardjono (2013) Sintesis dan uji aktivitas antikanker senyawa 1-(2-klorobenzoiloksi)urea dan 1-(4-klorobenzoiloksi)urea. Berkala Ilmiah Kimia Farmasi, 2 (1). pp. 16-20. ISSN 2302-8270

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Hydroxyurea or (HU) is a compound that has antineoplastic activity through a mechanism of inhibiting ribonucleotide reductase enzyme. To design new drugs, the physicochemical properties of drug molecules can be predicted before they are synthesized and purified. In silico test is a method to predict the activity of the compound to be synthesized. Ribonucleotide reductase was the main target or receptor of anticancer compounds such as HU and their derivatives, namely 1-(2-chlorobenzoyl-oxy)urea or 2-ClBOU and 1-(4-chlorobenzoyloxy)urea or 4-ClBOU. These compounds formed a complex with crystal structure of ribonucleotide reductase I enzym which was 2EUD. Bond energy in the form of rerank scores from both complexes were calculated with Molegro program. Rerank score score 2-ClBOU -81,1349 and 4-ClBOU -82,7887 while HU - 43.3565. From the results obtained could be predicted that 2-ClBOU and 4-ClBOU have greater anticancer activity than HU. Synthesis of These compounds were performed by reacting hydroxyurea with 2-chlorobenzoyl chloride or 4-chlorobenzoyl chloride. Purity test was by TLC and melting point determination were performed. The structure of compounds were confirmed using data from UV, IR, 1H-NMR, 13C-NMR, and MS/GC-MS spectra. In this study, 2-ClBOU and 4-ClBOU compounds have been succesfully synthesized and after in vitro anticancer activity was tested against HeLa cells, it was obtained 2-ClBOU IC50 94 µg/ml, 4-ClBOU IC50 84 µg/ml while IC50 HU 430 µg/ml. Can be concluded that 2-ClBOU and 4-ClBOU have greater anticancer activity than HU.

Item Type: Article
Uncontrolled Keywords: 1-(2-chlorobenzoyloxy)urea, 1-(4-chlorobenzoyloxy)urea in silico test, synthesis, anticancer activity test,
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi
Peer Review
Depositing User: Ika Rudianto
Date Deposited: 22 Jan 2017 18:02
Last Modified: 15 Jun 2017 20:21
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