The Role of p53 Protein Expression in Retinoblastoma Repository

The Role of p53 Protein Expression in Retinoblastoma

Soebagjo, Hendrian Dwikoloso and Fatmariyanti, Susy and Lutfi, Delfitri and Aulanni’am and Sumitro, Sutiman Bambang (2016) The Role of p53 Protein Expression in Retinoblastoma. European Journal of Biomedical and Phamnceutical Sciences, 3 (7). pp. 1-7. ISSN 2349-8870

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Abstract

This study was undertaken to demonstrate the expression of p53 in retinoblastoma. Thirty three retinoblastoma tissue samples of intratumoral retinoblastoma were tested with SDS-PAGE to find the expression of retinoblastoma protein, followed by Western blotting and immunohistochemistry to confirm p53 expression. The electrophoresis examination identified 10 major protein fractions with molecular weight from 103 – 14 kDa. Poorly differentiated retinoblastoma samples revealed 10 protein fractions (molecular weight 103 – 14 kDa) and well differentiated retinoblastoma revealed 9 protein fractions (molecular weight from 97 – 14 kDa). Western blot and immunohistochemistry assay using monoclonal antibody p53 showed that samples are positively expressed p53. No significant correlation was found between p53 expression and differentiation of retinoblastoma (p<0.429, C = 0,214).

Item Type:

Article

Uncontrolled Keywords:

retinoblastoma, differentiation, p53 expression.

Subjects:

R Medicine > RE Ophthalmology

Divisions:

01. Fakultas Kedokteran > Ilmu Penyakit Mata
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Creators:

Creators	NIM
Soebagjo, Hendrian Dwikoloso	UNSPECIFIED
Fatmariyanti, Susy	UNSPECIFIED
Lutfi, Delfitri	UNSPECIFIED
Aulanni’am	UNSPECIFIED
Sumitro, Sutiman Bambang	UNSPECIFIED

Depositing User:

Bayu Yulianti

Date Deposited:

18 Feb 2017 14:31

Last Modified:

18 Feb 2017 14:31

URI:

http://repository.unair.ac.id/id/eprint/52998

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