ARISKA PUTRI HIDAYATHILLAH, 101414553024 (2016) INDEKS KEJADIAN TUBERKULOSIS RESISTEN OBAT (TB-MDR) PADA PENDERITA TUBERKULOSIS DI KABUPATEN GRESIK JAWA TIMUR. Thesis thesis, Universitas Airlangga.

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Abstract

Introduction: The bacteria that causing tuberculosis can become resistant to antimicrobial drugs which used to kill the TB germs. The resistance of M. Tuberculosis germ to anti-tuberculosis drugs (OAT) is a state in which germs can no longer be killed by first-lineOAT, at least to isoniazid and rifampicin. Indonesia is on 8th out of 27 countries that have a high burden of TB - MDR. Gresik district is not among the big 10 districts in East Java, which has the highest TB incidence, but Gresik is a district with the highest proportion of TB - MDR casesamong TB cases in East Java in 2015. Methods: the research design of this study was case – control. The case population of the study were all patients with TB-MDR in Gresik in 2015, and the control population were all patients with TBin Gresik in 2015 and declared as cured. Results: Based on the analysis using multiple logistic regression, index of incidence of MDR-TB obtained as PMO (OR = 8.470 CI95% (1.704 - 42.096), regularity (OR = 17.905 CI95% (3.704 - 86.553), side effects of drugs (OR = 8.115 CI95% (1.503 - 43.882), the result of previous treatment (OR = 6.860 CI95% (1.480 - 31.790) and DM (OR = 7.486 CI95% (1.465 to 38.253) Conclusion: It can be concluded that the index of incidence of TB-MDR was - 4.359 + 2.137 (PMO (not exist)) + 2.885 (regularity (irregular)) + 2.094 (drug side effects (positive)) + 1.926 (previous treatment outcomes (failed or drop out)) + 2.013 (diabetes mellitus (exist)) Keywords: TB-MDR, Risk Factors, Gresik District

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