ERNA ROMAULI BORU TOBING, NIM011228156307 (2016) KESESUAIAN DIAGNOSTIK TROPONIN-I NEXT GENERATION DAN TROPONIN-I HIGH SENSITIVE PADA PASIEN DIDUGA SINDROMA KORONER AKUT. Thesis thesis, Universitas Airlangga.

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Abstract

Background: Acute coronary syndrome (ACS) is a manifestation of coronary heart disease (CHD), consisting of Unstable Angina and Acute Myocardial Infarction (AMI). Increasing Troponin I (TnI) level is one of criteria for diagnosing AMI. Some methods of TnI assay has been developed, such as high sensitive TnI (hsTnI)and next generation TnI (ngTnI). The aim of this study was to analyze the diagnostic concordance between ngTnI and hsTnI in suspected ACS patients. Methods: This was a cross sectional study done in the Dr. Soetomo Hospital Surabaya in March-July 2016. The 82 patients with angina pectoris were examined for ngTnI level using Fluorescent Energy Transfer Latex method (Alere Triage MeterPro®) and hsTnI level using Chemiluminescent Enzyme Immunoassay method (Mitsubishi Pathfast®). Results: Forty four percent subjects were diagnosed as ACS, and 56% were non ACS. There was a significant concordance between ngTnI and hsTnI results in ACS patients (kappa: 0.738). The sensitivities of ngTnI and hsTnI level to diagnose IMA with a cut off 0.02 ng/ml were 100%, and the specificities were 56% and 64%, respectively. Correlation analysis between ngTnI level and hsTnI by Spearman test revealed a correlation coefficient rho (ρ) = 0.826 (p <0.01). Conclusion & suggestion: There was a diagnostic concordance between ngTnI and hsTnI in suspected ACS patients. Both TnI assays showed a good value for diagnosing ACS. Further research is needed for analyzing the prognostic value of TnI.

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