LAILA NURHIDAYATUS SHOLIKIN, 051211131167 (2016) IDENTIFIKASI FRAKSI AKTIF ANTIVIRUS HEPATITIS C DARI EKSTRAK ETANOL 80% HERBA Scoparia dulcis Linn. Skripsi thesis, Universitas Airlangga.
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Abstract
Scoparia dulcis is a plant that belongs to Scrophulariaceae family. It used traditionally as remedies for stomach trouble. Previous study showed that ethanol extract 80% of Scoparia dulcis herbs has antiviral activity againts hepatitis C virus JFH1a infected hepatocyte cell Huh7it with IC50 value of 17.79 μg/ml. Further study is conducted on ethanol extract 80% of Scoparia dulcis herbs by using fractination liquid-liquid method and dichloromethane, ethyl acetate, and butanol as the solvent. The result showed that the dichloromethane fraction of ethanol extract 80% of Scoparia dulcis herbs has IC50 value 5.32 ± 0.50 μg/ml. Ethyl acetate, butanol and water fraction of ethanol extract 80% of Scoparia dulcis herbs has IC50 value more than 100μg/ml. Dichloromethane fraction of 80% ethanol extract of Scoparia dulcis showed the highest activity (IC50 5.32 ± 0.50 μg/ml) compare to ethyl acetate, butanol, and water fractions (IC50 more than 100 μg/ml). Dichloromethane fraction of 80% ethanol extract of Scoparia dulcis has the highest toxicity with CC50 value 23,31 μg/ml and SI 4,38. Ethyl acetate, butanol fraction, and water fraction of ethanol extract 80% of Scoparia dulcis herbs has CC50 value more than 800μg/ml and SI more than 8. In conclusion, dichloromethane fraction of 80% ethanol extract of Scoparia dulcis has the highest antiviral activity hepatitis C, but it also toxic. It has chemical compound such as chlorophyll, terpenoid, and flavonoid. Keyword : Scoparia dulcis, extract, fractions, antiHepatitis C virus
| Item Type: | Thesis (Skripsi) | |||||||||
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| Additional Information: | KKB KK-2 FF.FT. 21-16 Sho i | |||||||||
| Uncontrolled Keywords: | Scoparia dulcis, extract, fractions, antiHepatitis C virus | |||||||||
| Subjects: | R Medicine > RC Internal medicine > RC31-1245 Internal medicine R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica |
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| Divisions: | 05. Fakultas Farmasi > Farmakognosi Fitokimia | |||||||||
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| Depositing User: | Tatik Poedjijarti | |||||||||
| Date Deposited: | 02 Apr 2017 18:33 | |||||||||
| Last Modified: | 30 Aug 2017 02:40 | |||||||||
| URI: | http://repository.unair.ac.id/id/eprint/55652 | |||||||||
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