Melani Hariyadi Dewi and Tutiek, Purwanti and Destia, Wardhani and Sisilia, Ermawahyuningtyas (2015) Physical Evaluations of Freeze-Dried Ca-Alginate Microspheres Containing Ovalbumin Using Different Lyoprotectants. In: Controlled Release & Drug Delivery Symposium 2015, 15 -16 Agustus 2015, Universiti Kebangsaan Malaysia.

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Abstract

The main objective of the research was to investigate physical evaluations of freeze-dried ovalbumin loaded-Ca alginate microspheres. This research used alginate, CaCl2 and lyoprotectants (maltodextrin, lactose or sucrose). The freeze-dried microspheres were subjected to micromeritics properties including moisture content,angle of repose angle of repose, bulk density, tapped density, Carr’s index, and Hausner's ratio. Results showed that the prepared microspheres were spherical with particle size of microspheres using lyoprotectant maltodextrin,lactose and sucrose were 2.32, 2.15 and 2.05 pm respectively. Moisture content of freeze-dried microspheres contains maltodextrin and sucrose were about 4%, lower than microspheres using lactose of about 6.66%. Bulk densities and tapped densities were in the range of 0.2634 to 0.3232 and 0.3160 to 0.4040 respectively. Carr's index (Cl) and Hausner's ratio(HR) were in the range from 15 to 23% and 1.1765 to 1.2988 respectively. Microspheres produced using lyoprotectant sucrose resulted in good flow properties with Cl of 15% and HR of 1.1765, whereas other formulas showed fair flow. Almost all freeze-dried ovalbumin-loaded alginate microspheres resulted in small spherical microspheres with less water content and good flow properties.

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