PUTRI LAILATUL AFIDAH, 051211133078 (2016) SINTESIS METIL 4-HIDROKSI-3-METOKSISINAMAT DAN PROPIL 4-HIDROKSI-3-METOKSISINAMAT MENGGUNAKAN MICROWAVE OVEN. Skripsi thesis, Universitas Airlangga.

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Abstract

SYNTHESIS METHYL 4 - HYDROXY- 3 - METHOXYCINNAMATE AND PROPYL 4 - HYDROXY- 3 - METHOXYCINNAMATE USING THE MICROWAVE OVEN Putri Lailatul Afidah In the previous studies showed that 4-hydroxy-3-methoxycinnamate acid has a lot of bioactivities, such as antioxidant by binding free radical. It is promising to be modified as antioxidant, due to its characteristic structure. Lipophilicity of 4-hidroxy-3-methoxycinnamate acid can be improved through modification into ester. In this study, 4-hydroxy-3- methoxycinnamate acid as the starting material was reacted with alcohol (methanol or propanol) to obtain methyl 4-hydroxy-3-methoxycinnamate and propyl 4-hydroxy-3-methoxycinnamate. This synthesis was carried out using microwave irradiation. Microwave irradiation was one of the methods that could reducing reaction time and increasing yield. The product was purified by column chromatography to give a purified product, which was analyzed using TLC test, melting point test, IR, 1H-NMR, and UV spectroscopies to determine its structure. It can be concluded that the products are methyl 4-hydroxy-3-methoxycinnamate (39,8% yield) and propyl 4-hydroxy-3-methoxycinnamate (18,5% yield). Keywords : 4-hydroxy-3-methoxycinnamate acid, methanol, propanol, methyl 4-hydroxy-3-methoxycinnamate, propyl 4-hydroxy- 3-methoxycinnamate, microwave irradiation

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