ADE FILI SOPHIA`, 051211131030 (2016) SINTESIS SENYAWA ASAM 2-(BENZOILOKSI)-5-METOKSI BENZOAT DAN UJI AKTIVITAS ANALGESIK PADA MENCIT (Mus musculus). Thesis thesis, Universitas Airlangga.

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Abstract

Synthesis of 2-(benzoyloxy)-5-methoxybenzoate and Analgesic Activity Test in Mice (Mus musculus) Ade Fili Sophia In an effort to enhance the analgesic activity of acetosal, the structural modification of acetosal was performed by synthesizing derivative 2- (benzoyloxy) -5-methoxy benzoate. The compound 2- (benzoyloxy) -5-methoxy benzoate is salicylic acid derivative was synthesized and tested using a writhing test in mice (Mus musculus). Synthesis reaction is a Schotten-Baumann reaction using reagent 5- methoxy salicylic acid and benzoyl chloride in THF as a solvent. For the alkaline condition is used pyridine which also serves as a catalyst and neutralize HCl. The result was obtained by the synthesis is 52.4% in the form of a solid white powder that was insoluble in water. Its purity was tested by melting point test and Thin Layer Chromatography (TLC). The structure was confirmed by UV-Visible spectrophotometry, infrared spectrophotometry and 1H-NMR spectrometry. The result of analgesic activity was showed that the compound 2- (benzoyloxy) -5-methoxy benzoate had lower ED50 than acetosal. ED50 of 2- (benzoyloxy) -5-methoxy benzoate is 49.56 mg/kg body-weight and ED50 acetosal is 80.28 mg/kg body-weight. It concluded that 2- (benzoyloxy) -5-methoxy benzoate have higher analgesic activity than acetosal. Keyword: synthesis, 2- (benzoyloxy) -5-methoxy benzoate, analgesic activity

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