ACHMAD, FUAD HAFID and ACHMAD, RADJARAM and DWI, SETYAWAN (2013) Dissolution Enhancemnet of Curcumin by Hydroxypropy-β-Cyclodextrin Complexation. International journal of Pharmacy Pharmaceutical Sciences, 5 (3). pp. 401-405. ISSN 0975 - 1491

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Abstract

The purpose of this study describes the formation of inclusion complex by coevaporation of curcumin using hydroxypropyl-β- cyclodextrin as carriers, to improve the solubility and dissolution of drug. Methods: The preparation of inclusion complex was carried out by using solvent method. The drug and carrier were dissolved in alcohol and subjected to solvent evaporation by a rotary evaporator. The residual powder preparation was allowed to dry overnight in vacuum desiccator, pulverized and sieved through # 60 mesh. The invitro dissolution testing was performed media in HCl 0.1 N aqueous solution. Characterization of inclusion complex and physical mixture was further evaluation using differential thermal analysis (DTA), powder X-ray diffraction (PXRD), FTIR spectrophotometry and a scanning electron microscope (SEM). The results: Evaluation of the phase solubility studies revealed a AL type diagram with complexation of equimolar ratio and solubility constant of 30.09 mM -1 . In-vitro dissolution studies showed that the curcumin entrapped in coevaporated complexes dissolved much faster than the incomplexed dissolved drug and physical mixtures. X-ray diffraction indicated loss a crystalline nature of the drug, FTIR, DTA studies revealed no interaction between curcumin and HPβCD. Conclusions: Inclusion complex of curcumin with HPβCD appears to have the advantage of dissolution enhancement and that may lead to improved bioavailability.

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