Achmad Fuad Hafid, - and Aty Widyawaruyanti, - and Esti Eka Wardhani, - and Alsheila Andiska, - and Widjiati, - and Herra Studiawan, - (2010) Toxicity and teratogenic tests of ethanol extract of Artocarpus champeden stembark. In: International Conference On Medicinal Plants The Future of Medicinal Plant: From Plant to Medicine Surabaya, 21-22 July 2010, Faculty of Pharmacy Widya Mandala Chatolic University.

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Abstract

Artocarpus champeden (family Moraceae), known as "cempedak", is widely distributcd in Indonesia and has been traditionally used in malarial remedies. Our previous sfudy revealed that the ethanol extract of Artocarpus champeden stembark (EEAC) exihibited potent antimalarial activities against P.falciparum in vitro and P. berghei in vivo. Therefore, it is potential to develop EEAC as an antimalarial phytopharmaceutical product. The development of phytopharmaceutical product requires consistency in the efficacy, safety, and effectivity. This research was conducted to evaluate the safety of EEAC as an active material for antimalaria phyropharmaceutical product. Toxicity test in mice after oral administration was carried out. Acute toxicity test was conducted using the highest dose of 2l g/kg body weight/day. The result showced that EEAC was relatively non toxic. Subacute toxicity test was expressed by thc levels of ALT and AST activities in scrum. The result showed that EEAC was relatively safe. In addition, there was no significant difference in the observed ALT and AST activities in serum. Histopathological changes due to degeneration and necrosis were observed after 30 days oral administralion of EEAC at a dose of 1.90 mg/20 g body weight/day Thc teratogenic test was also conducted using the highest dose of 254.80 mg/20 g body weight/day. The result showed that there was no significant morphological deformity of mice fetus at organogencsis phasc after l0 days oral administration of EEAC

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