Nasruhan A and Suharjono and Joni Wahyuhadi (2014) Comparative Effectiveness Of Paracetamol And Metamizol As Antipyretics In Patients With Moderate And Severe Brain Injury In Dr. Soetomo Hospital, Surabaya. Folia Medica Indonesiana, 50 (3). pp. 187-190. ISSN 2355-8393

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Abstract

Patients with moderate and severe brain injury have increased recently. They were having a lot of complications namely seizures,hyperthermia, pain and several other complications. One of the most common complication in patients with moderate and severebrain injury is acute hyperthermia. Acetaminophen or Metamizole is often used for this case. The study of this clinical observation isto compare the effectiveness of Acetaminophen and Metamizole as an antipyretic in patients with moderate and severe brain injuriesin Dr. Soetomo hospital. The population of this study was patients with moderate and severe brain injuries in SMF neurosurgeryward in Dr. Soetomo hospital who obtained paracetamol and metamizol as the therapy. The study was taken from January to April2013. We studied 32 patients who had febrile episode, 8 patients with moderate brain injury and 8 patients with severe brain injuryreceived acetaminophen, 8 patients with moderate brain injury and 8 patients with severe brain injury who received metamizole byaxilla examination. Patient's temperature was measured before and 15, 30 minute, 1, 2, 3, 4, 5, 6 hours after drug infusion. Thisstudy demonstrates the effectiveness of acetaminophen and metamizole as an antipyretic in moderate brain injury were notsignificantly different (p = 0.583). The Effectiveness of acetaminophen and metamizole as antipyretic in severe brain injury does nothave a significant difference (p = 0.651). Acetaminophen and metamizol have the same antipyretic activity in moderate and severebrain injury in Dr.Soetomo hospital Surabaya. (FMI 2014;50:187-190)

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