UNIKMAH WULAN NING ASIH, 051211132044 (2016) PENGARUH KADAR EUDRAGIT® S 100 SEBAGAI MATRIK TERHADAP KARAKTERISTIK FISIK DAN DAYA PROTEKSI MIKROPARTIKEL Bifidobacterium bifidum. Skripsi thesis, Universitas Airlangga.
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Abstract
Probiotics can confer a health benefit in a minimum concentration 106 cfu/g. The bacteria that is widely used as probiotic is Bifidobacterium bifidum. Bifidobacterium bifidum is not resistant to the acid environment in the stomach but it work in basic environment in the intestine. So, the bacteria made in the form of microparticles encapsulated by spray drying with Eudragit® S 100 to protect the bacteria. Microencapsulation is a process in which the active ingredient trapped inside polymer and protect from environmental influences then released to the target site. It made into three concentrations of Eudragit® S 100 (0,5 %, 1,0 %, and 1,5 %). Then, these three formula tested on the physical characteristics of microparticles and protection ability of microparticles. The result is known that in formula I have a porous morphology and plenty basin, formula II has a spherical and smooth surface while the formula III has a spherical morphology and a little basin. The Increasing concentrations of Eudragit® S 100 in formula I, II, and III causes the particle size increases but the moisture content decreases. The results on the protection ability of microparticles shows that protection with increasing concentrations of Eudragit® S 100 increase against heat of spray drying process but under exposure of simulated gastric fluid (pH 1,2) the protection ability increase in formula I to II and decrease in formula III. Data protection ability analyzed using One-Way ANOVA and showed that there was no significant difference among the three formulas in the protection ability againts heat of spray drying proces and protection ability under exposure of simulated gastric fluid.
| Item Type: | Thesis (Skripsi) | |||||||||
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| Additional Information: | KKB KK-2 FF F 03-16 Asi p | |||||||||
| Uncontrolled Keywords: | Micoencapsulation, Spray drying, Eudragit® S 100, Probiotic, Bifidobacterium bifidum, Physical characteristic of microparticles, Protection ability. | |||||||||
| Subjects: | Q Science > QR Microbiology > QR75-99.5 Bacteria R Medicine > RM Therapeutics. Pharmacology |
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| Divisions: | 05. Fakultas Farmasi > Farmastika | |||||||||
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| Depositing User: | sukartini sukartini | |||||||||
| Date Deposited: | 09 May 2017 16:51 | |||||||||
| Last Modified: | 05 Jul 2017 20:59 | |||||||||
| URI: | http://repository.unair.ac.id/id/eprint/57309 | |||||||||
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