VENNIE WANDA APRIONA, 051211132041 (2016) KARAKTERISASI KOMPLEKS INKLUSI ASAM P-METOKSISINAMAT (APMS)-β-SIKLODEKSTRIN (Dibuat dengan Metode Slurry). Skripsi thesis, Universitas Airlangga.

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Abstract

p-methoxycinnamic acid (pMCA), a substance obtained from the hydrolysis of ethyl p-methoxycinnamate (EpMC). pMCA has an analgesic activity. pMCA has very low solubility in water, which affect on dissolution ratelimited absorbtion of this substance. The purpose of this study was to increase the aqueous solubility of pMCA using β-cyclodextrin (βCD) as a complexing agent. The 1:1 pMCA-βCD molar ratio was chosen to produce the inclusion complex, by slurry method. In the slurry method, pMCA and β-CD were finely suspended in the water at ambient temperature with vigorous stirring. The characterization was compared with pMCA, β-CD, and the physical mixture of pMCA a nd β -CD. The inclusion complex formed was characterized using X-ray diffraction, Differential Thermal Analysis (DTA), and Fourier Transform Infrared Spectroscopy (FTIR), also performed dissolution test. Xray result showed that there was a decreasing in diffraction intensity of pMCA in the inclusion complex compared to the pMCA in the physical mixture. DTA result showed crystalline characteristic of inclusion complex became amorphous with 142,9 °C of melting point, FTIR studies showed there were shift or changes in the spectrum which due to the inclusion complex. The dissolution rate and dissolution efficiency of pMCA-β-cyclodextrin inclusion complex was significantly higher than pMCA, and physical mixture of pMCA-β-cyclodextrin. The result showed that formation of inclusion complexes produce different characteristics in comparison with the single compound of pMCA, β-CD, and the physical mixture of pMCA-βCD and also increase the dissolution rate of pMCA. These changing of characteristic and dissolutin rate result proved that inclusion complex was formed. Keyword: p-methoxycinnamic acid, β-cyclodextrin, inclusion complex, characterization, slurry method.

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