WISNU PRASETYO UTOMO, 051211132042 (2016) PENGARUH pH BASA TERHADAP STABILITAS SALISILAMIDA. Skripsi thesis, Universitas Airlangga.
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Abstract
Salicylamide is a derivative of salicylic acid with analgesic effect. Salicylamide is a weak acid with value of pKa 8,2. It causes salicylamide become unstable at a range of 2 units above the pKa. The stability of salicylamide in various pH (7,0; 8,0; 9,0; 10,0; and 11,0) has been studied. The buffer solution 3000 mg/L of salicylamide in various pH were studied at 40 ± 0,5oC for 6 hours. Then it was determined at different times (0h, 1h, 2h, 4h, and 6h) and analysed using Thin Layer Chromatography (TLC) – Densitometry. The analysis is done using silica gel TLC plates 60 F254 as the stationary phase and a mixture of dichloromethane : acetone (4 : 1 v/v) as the mobile phase. The results showed that salicylamide follows first order reaction. Salicylamide at various pH buffer solution (7,0; 8,0; 9,0; 10,0; and 11,0) have rate constant (k) value 2,30.10-2 ± 1,22.10-2 ; 3,73.10-2 ± 1,89.10-2 ; 2,06.10-2 ± 0,54.10-2; 3,64.10-2 ± 0,39.10-2; and 1,40.10-2 ± 0,28.10-2 hour-1, respectively. Rate constant at pH 11 is the lowest than others due to resonance effect and resistance to nucleophilic attack by hydroxide ion. Keywords : salicylamide, stability, tlc – densitometry, pH
| Item Type: | Thesis (Skripsi) | |||||||||
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| Additional Information: | KKB KK-2 FF. F. 58-16 Uto p | |||||||||
| Uncontrolled Keywords: | salicylamide, stability, tlc – densitometry, pH | |||||||||
| Subjects: | R Medicine > RM Therapeutics. Pharmacology > RM300-666 Drugs and their actions R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica |
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| Divisions: | 05. Fakultas Farmasi > Farmastika | |||||||||
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| Depositing User: | Tatik Poedjijarti | |||||||||
| Date Deposited: | 16 May 2017 19:50 | |||||||||
| Last Modified: | 16 May 2017 19:50 | |||||||||
| URI: | http://repository.unair.ac.id/id/eprint/57452 | |||||||||
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