RIZKA FARIZKA, 051211131016 (2016) PENINGKATAN KELARUTAN DAN LAJU DISOLUSI QUERCETIN MELALUI PEMBENTUKAN KOKRISTAL QUERCETINASAM SUKSINAT DENGAN METODE PENGUAPAN PELARUT. Skripsi thesis, Universitas Airlangga.
|
Text (ABSTRAK)
ABSTRACT.pdf Download (301kB) | Preview |
|
![[img]](https://repository.unair.ac.id/style/images/fileicons/text.png) |
Text (FULL TEXT)
FF. F. 12-16 Far p.pdf Restricted to Registered users only Download (1MB) | Request a copy |
Abstract
Quercetin is know as a high antioxidant. And quercetin classified as Biopharmaceutical Class II (BCS II) which has poor solubility in aqueous media and high permeability. Cocrystal has been studied by many researcher as a metode to improve solubility and dissolution rate. The aim of this study is to compare the quercetine-succinic acide cocrystal (1:1, 1:2 and 1:3) solubility and dissolution rate with physical mixture (1:1, 1:2 and 1:3) and quercetin it self. The result of solubility and dissolution test were carried out to determine quercetine-succinic acid cocrystal properties. Solubility test dan dissolution test show that there is significant increase in quercetin-succinic acid cocrystal at a ratio of 1:1. And there is no significant increase in quercetin-succinic acid cocrystal at a ratio of 1:2 and 1:3.
| Item Type: | Thesis (Skripsi) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Additional Information: | KKB KK-2 FF F 12-16 Far p | |||||||||
| Uncontrolled Keywords: | Quercetine, Succinic acid, Cocrystal, Solubility, Dissolution rate | |||||||||
| Subjects: | R Medicine > RS Pharmacy and materia medica | |||||||||
| Divisions: | 05. Fakultas Farmasi > Farmastika | |||||||||
| Creators: |
|
|||||||||
| Contributors: |
|
|||||||||
| Depositing User: | sukartini sukartini | |||||||||
| Date Deposited: | 18 May 2017 00:01 | |||||||||
| Last Modified: | 18 May 2017 00:01 | |||||||||
| URI: | http://repository.unair.ac.id/id/eprint/57500 | |||||||||
| Sosial Share: | ||||||||||
Actions (login required)
 |
View Item |