LINA NOVITASARI, 051211131070 (2016) PENGARUH KADAR EUDRAGIT® S-100 TERHADAP KARAKTERISTIK FISIK DAN EFISIENSI PENJEBAKAN Lactobacillus casei DALAM MIKROPARTIKEL. Skripsi thesis, Universitas Airlangga.

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Abstract

Microencapsulation is a process of enclosing micron-sized particle in a polymeric shell as a physical barrier against stress condisitions. It is suitable for sensitive substances such as probiotic bacteria that are not resistant to acidic environments and high temperatures. Eudragit® S-100 was used as a matrices polymer with the objective of enhancing survival of the probiotic bacteria and keeping them during exposure to the adverse conditions of the gastro-intestinal tract. The aim of this study was to determine effect of Eudragit® S-100 concentration with physical characteristic and Lactobacillus casei encapsulation efficiency in microparticle by spray drying method. Lactobacillus casei was made into microparticle by spray drying method in 120oC inlet temperature with three different concentration of Eudragit® S-100. Three different formula were named formula I, formula II, formula III with 0,5%; 1,0%; and 1,5% concentration of Eudragit® S-100. Physical characteristic and encapsulation efficiency test were performed in all formula. The result showed that microparticle morphology have spherical shape and smooth surface only in formula II which contain Eudragit® S-100 concentration 1,0%. Moisture content was decreased with increasing Eudragit® S-100 concentration. The largest particle size of microparticle was obtained by formula II. Encapsulation efficiency of microparticle decreased with increasing Eudragit® S-100 concentration (p<0,05). The best encapsulation efficiency was obtained by formula I with a percentage of 67,33% ± 2,87.

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