FIDYANA NOOR ALIFYA, 051211132012 (2016) PENGARUH KADAR EUDRAGIT® S 100 TERHADAP KARAKTERISTIK FISIK MIKROPARTIKEL DAN EFEK IMUNOMODULATOR Bifidobacterium bifidum. Skripsi thesis, Universitas Airlangga.

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Abstract

Drug delivery system can be developed by microparticle system and microencapsulation used as the production method. Microencapsulation can protecting an active subtance from extreme condition and producing solid microparticles (1-1000 μm). In this study, pulsatile release used as release system, Eudragit® S 100 used as matrix and Bifidobacterium bifidum used as the active substance. Bifidobacterium bifidum has immunomodulatory effect in the intestine when the concentration is ≥ 106 cfu/ml but it is not stable in the gastric fluid. Mincroencapsulation method in this study is spray dry because it is the common method in the probiotic encapsulation. Three different Eudragit® S 100 concentrations, 0.5%; 1.0%; and 1.5%, were named formula I, formula II, and formula III respectively used as matrix of Bifidobacterium bifidum. Physical characteristic and immunomodulatory were performed in all formula. The particle size of all formula were variated in the range 2.265-9.060 μm. The moisture contain showed in the formula I, formula II, formula II are 20.78±0.44 %, 8.99±2.09 %, and 8.83±0.39% respectively. The result of Microparticle morphology : formula I is irregular shape and porous, formula II is spheris with few concave surface, formula III is is spheris with more concave surface. Formula I has the highest immunomadulatory effect which showed by the highest hemaglutinine titer than other formula.

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