ATIKAH ISMU PUTRI ANANDA, 051211131043 (2016) UJI AKTIVITAS MIKROBIOLOGI SIPROFLOKSASIN DALAM IMPLAN TULANG TERHADAP Escherichia coli ATCC 25922 (KOMPOSIT IMPLAN : KITOSAN - BOVINE HYDROXYAPATITE DENGAN CROSS-LINKER GLUTARALDEHID). Skripsi thesis, Universitas Airlangga.

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Abstract

Osteomyelitis is an infection of the bone complications caused by bacteria, one of which is Escherichia coli. Ciprofloxacin can be given as a treatment, because ciprofloxacin is a broad-spectrum antibiotic and can penetrate into the tissues of the body.in a previous study, has made ciprofloxacin dosage form in implant to restore the infection with two concentrations of glutaraldehyde cross-liker, is 0.3% and 0.5%. Result of the released study showes that implant could release drug in controlled and included in the range therapeutik (2-50μg/mL) In this research the microbial activity of the ciprofloxacin using a diffusion method to Escherichia coli ATCC 25922. This assay using sample result of release study, which was obtained in previous studies. Based on the results of the study, showed that the averagepotency antibiotics for 29 days on a formula of 0.3% was 112.76% and at 0.5% was 111.86%. Based on these results, the antibiotic ciprofloxacin in the implants demonstrated the ability to inhibit bacterial growth. The average value of the potential generated by each eligible antibiotic potency test that was 80% -125% and increasing concentration of cross-linker was not significantly affect to the potency of ciprofloxacin in bone implant in every day microbial assay.

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