DHIMAS TONI ANGGER PRAMBUDI, 061311133118 (2017) UJI TOKSISITAS AKUT PARE (Momordica c PERUBAHAN HISTOPATOLOGI HATI DAN GINJAL DHIMAS TONI ANGGER PRAMBUDI FAKULTAS KEDOKTERAN FRAKSI ALKALOID BUAH charanthia L) TERHADAP MENCIT (Mus musculus). Skripsi thesis, Universitas Airlangga.

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Abstract

This study aims to determine the acute toxicity alkaloid fraction of bittermelon (Momordica charanthia L) in mice (Mus musculus) to knowing lethal dose 50% (LD50) and histopathologic changes on liver and kidneys. This research used 30 female mice, were randomly divided into six treatment groups, i.e. P0: healthy mice given CMC Na 0,5%; P1: mice given 0.3 g/kgbw alkaloid fraction of bittermelon; P2: mice given 0.8 g/kgbw alkaloid fraction of bittermelon; P3: mice given 2.1 g/kgbw alkaloid fraction of bittermelon; P4: mice given 5.6 g/kgbw alkaloid fraction of bittermelon and P5: mice given 15 g/kgbw alkaloid fraction of bittermelon. Measurement of histopathologic changes using Brunt scoring method based on the percent of degeneration and necrosis. Data analysis using Kruskal Wallis and Mann Whitney test. The results showed that the alkaloid fraction of bittermelon cause significant damage (P <0.05) in the liver and kidney cells of mice and until dose 15 g/kgbw can’t cause death of the mice so that the alkaloid fraction of bittermelon including medicinal ingredients as not harmful.

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