FINA FRANSISKA SAGALA, 061311133146 (2017) PENGARUH PEMBERIAN VAKSIN SUBUNIT LIPOPOLISAKARIDA Brucella abortus DALAM ADJUVAN MONTANIDE ISA 70 TERHADAP PEMBENTUKAN ANTIBODI DAN INTERLEUKIN-2 PADA DOMBA. Skripsi thesis, Universitas Airlangga.

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Abstract

The aim of this study was to understand the influence of Brucella abortus Lipopolysaccharide subunit vaccine on adjuvant Montanide ISA 70 of sheep antibody and interleukin-2 production. This study used 18 male sheeps as experimental animals. This study was divided into 3 treatment groups and 6 repetitive groups. The treatment groups consist of P0 = control, P1 = 50 μg/ml LPS Brucella abortus on adjuvant Montanide ISA 70 and P2 = 100 μg/ml LPS Brucella abortus on adjuvant Montanide ISA 70. Observation are scheduled on the 2nd week and 4th week after vaccination. This study was analyzed using ANOVA Repeated Measures, continued by Least Significant Diference. The result of this study shows the giving of Brucella abortus lipopolysaccharide subunit vaccine in adjuvant Montanide ISA 70 can affect the production of antibody and interleukin-2 on sheep. The dose difference affects antibody movement and interleukin-2 content on sheep. The dose of 100 μg/ml produce greater antibodies OD value than the dose of 50 μg/ml. The dose of 50 μg/ml produce the levels of interleukin-2 greater than the dose of 100 μg/ml. The post vaccination time on the 2nd week and 4th week doesn't affects the antibody and interleukin-2 production on sheep.

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