PUPUT ADE WAHYUNINGTYAS, 061311133179 (2017) POTENSI HEPATOPROTEKTIF PASTA TOMAT (Lycopersicon esculentum) TERHADAP GAMBARAN HISTOPATOLOGI HEPAR MENCIT (Mus musculus) YANG DIPAPAR BORAKS. Skripsi thesis, Universitas Airlangga.

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Abstract

The purpose of this research was to evaluate the hepatoprotective potency of tomato paste (Lycopersicon esculentum) against histopathological appereance of mice (Mus musculus) liver exposed to borax. Twenty four mice (Mus musculus) with 60-90 day ages and 20 g avarage of body weight were divided into six groups (P0 , P1, P2, P3, P4, and P5). P0 was treated with sterile aquadest 0,1 ml/20g Bw/day, P1 was treated with borax 7,5 mg/20g Bw/day, P2 was treated with tomato paste 300mg/20g Bw/day, P3 was treated with tomato paste 150mg/20g Bw/day and borax 7,5 mg/20g Bw/day, P4 was treated with tomato paste 300mg/20g Bw/day and borax 7,5 mg/20g Bw/day, and P5 was treated with tomato paste 450mg/20g Bw/day and borax 7,5 mg/20g Bw/day. This research has been conducted for 14 days. The data of histopatological appereance were analyzed with Kruskal-Wallis and continued with Man-Whitney. Result showed there were significant (p<0.05) different between treatment groups. This research concluded that tomato paste with dose 450mg/20g BB daily can prevent the damage of hepar that exposed to borax.

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