RISQIA DAMAYANTI, 061311133236 (2017) PENGARUH PEMBERIAN EKSTRAK UMBI BAWANG DAYAK (Eleutherine palmifolia) TERHADAP KADAR MALONDIALDEHIDA (MDA) HEPAR TIKUS PUTIH JANTAN GALUR WISTAR YANG DIINDUKSI ALOKSAN. Skripsi thesis, Universitas Airlangga.

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Abstract

This research aimed to determine the effect of Dayak onion tuber extract (Eleutherine palmifolia) given by per oral in lowering levels of malondialdehyde (MDA) in liver of white male rat (Rattus norvegicus) strain Wistar which was induced by alloxan. The 24 experimental male Wistar rats were divided into 6 groups. The negative control group K(-) were given with aquabidest and CMC-Na 1% during the therapy period, the positive control group K(+) were given with alloxan 110 mg / kg bw, the group of drug control K(O) were given with alloxan and oral therapy with metformin 9 mg / 200g bw / day, the treatment group 1 (P1) were given with alloxan and per oral therapy with extract of Dayak onion tuber 100 mg / kg bw, the treatment group 2 (P2) were given with alloxan and per oral therapywith extract of Dayak onion tuber 200 mg / kg bw, and the treatment group 3 (P3) were given with alloxan and per oral therapy with extract of Dayak onion tuber 400 mg / kg bw. The therapy was given for 14 days, all rats were sacrificed and liver MDA level were examined with thiobarbituricacid(TBA) methods. The result of the data analysis test using one-way ANOVA (Analysis of Variance) showed that there were significant differences between the group of animals that received standard feed (

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